About the Role
TigaTx, a Boston-based startup, is seeking a highly motivated, detail-oriented, proactive Senior Research Associate/Associate Scientist to join our team. The successful candidate will support the development of IgA-based antibody therapeutics to help unleash the tumor killing power of neutrophils by testing and executing protein and cell-based immunoassays. The ideal candidate will be highly organized, efficient, and careful in their approach to science with excellent interpersonal skills and should enjoy collaborating as a team player in a fast-paced, exciting, ever-changing startup environment.
Key Responsibilities
Requirements
About TigaTx
TigaTx is developing engineered IgA monoclonal antibodies to unleash the tumor killing power of neutrophils, thereby providing a new class of medicines for the treatment of cancer patients.
Neutrophils have emerged as playing an increasing role in cancer and being an important component of the tumor microenvironment. Neutrophils, including immunosuppressive neutrophils (aka PMN-MDSC), express FcαRI (CD89), the main receptor for the IgA Fc region. Opsonization of tumor cells by IgA will lead to IgA binding to the FcαRI on neutrophils, thus converting neutrophils into potent tumor killer cells.
The company was founded in 2018 based on the groundbreaking scientific work of Dr. Leusen’s lab at the University Medical Center Utrecht in the Netherlands.
TigaTx is developing its preclinical programs in stealth mode after securing substantial seed financing from an international consortium of top-tier investors.